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Artículos 2012

J. Portilla, J. Quiroga, M. Nogueras, J. Cobo, Regioselective synthesis of fused pyrazolo[1,5-a]pyrimidines by reaction of 5-amino-1H-pyrazoles and -dicarbonyl compounds containing 5-membered rings – Tetrahedron, 68, 988-994.




J. Quiroga, Y. Díaz, J. Cobo, C. Glidewell, Hydrogen-bonded assembly in six closely related pyrazolo[3,4-b]pyridine derivatives; a simple chain, three types of chains of rings, and a complex sheet structure – Acta Cryst., C68, 12-18.


J. Quiroga,   J. Gálvez,   J. Cobo, C. Glidewell , Methyl (3aRS,3cRS,6cSR,7RS,8RS,8aSR)-2,5-bis(4-chlorophenyl)- 7,9-bis(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4,6- tetraoxo-dodecahydro-1H-dipyrrolo[3,4-a:3',4'-f]pyrrolizine-3-carboxylate bis(dimethylformamide): a three-dimensional hydrogen-bonded framework – Acta Cryst., C68, 439-442.


A. Insuasty, B. Insuasty, J. Cobo, C. Glidewell, (Z)-5-[(5-Methyl-1H-imidazol-4-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one monohydrate: a three-dimensional hydrogen-bonded framework structure - Acta Cryst. C., 68, 468-471 (2012). A. Insuasty, B. Insuasty, J. Cobo, C. Glidewell, (Z)-5-[(5-Methyl-1H-imidazol-4-yl)-methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one monohydrate: a threedimensionalhydrogen-bonded framework structure - Acta Cryst., C68, 468-471.


R. Abonia, D. Insuasty, J. C. Castillo, B. Insuasty, J. Quiroga, M. Nogueras, J. Cobo, Synthesis of novel quinoline-2-one based chalcones of potential anti-tumor activity - Eur. J. Med. Chem., 57, 29-40. 




J. Quiroga, N. E. Sánchez, P. Acosta, B. Insuasty, R. Abonia, Microwave-assisted synthesis of fused pyrazolo[3,4-b]pyrazines by the reaction of ortho-aminonitrosopyrazoles and cyclic β-diketones - Tetrahedron Lett. 53, 3181-3187. 



P. de la Torre, L. Astudillo Saavedra, J. Caballero, J. Quiroga, J. H. Alzate-Morales, M. Gutiérrez Cabrera, J. Trilleras, A novel class of selective acetylcholinesterase inhibitors: Synthesis and evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3-heteroarylacrylonitriles – Molecules, 17, 12072-12085.




B. Insuasty, L. Chamizo, J. Muñoz, A. Tigreros,  J. Quiroga, R. Abonía, M. Nogueras, J. Cobo, Synthesis of 1-substituted 3-aryl-5-aryl(hetaryl)-2-pyrazolines and study of their antitumor activity – Archiv Pharm., 345, 275-286. 


B. Insuasty, A. García, J. G. Bueno-Sánchez, J. Quiroga, R. Abonia, A. Ortiz, Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives – Archiv Pharm., 345, 739-744. 

J. C. Castillo, M. Presset, R. Abonia, Y. Coquerel, J. Rodriguez, Microwave-Assisted Domino Benzannulation of α-Oxo Ketenes: Preparation of 1,3-Dihydro-2H-1,5-benzodiazepin-2-ones - Eur. J. Org. Chem. 2012, 2338-2345. 


H. Insuasty, B. Insuasty, E. Castro, J. Quiroga, R. Abonia, M. Nogueras, J. Cobo, Three practical approaches for the synthesis of novel 4,7-dihetarylpyrazolo[1,5-a][1,3,5]triazines – Tetrahedron, 68, 9384-9390. 


E. Cortés, L. Méndez, E. G. Mata, R. Abonia, J. Quiroga, B. Insuasty, A strategy for the synthesis of 3-aryl-1,2,4-benzotriazines via intramolecular cyclization of solid-supported o-hydrazidoanilines – Molecular Diversity16, 839-846.


H. Insuasty, S. Estrada, J. Quiroga, B. Insuasty, R. Abonia, M. Nogueras, J. Cobo,  Solvent-free microwave-assisted synthesis of novel 4-hetarylpyrazolo[1,5-a][1,3,5]triazines – J. Heterocyclic Chem. 49, 1339-1345 (2012). 
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